Rho Signaling

Wallerian degeneration involves Rho/Rho-kinase signaling.

Local axon degeneration is a common pathological feature of many neurodegenerative diseases, whereas the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of Rho. Nogo-66, a myelin-derived inhibitor of axon regeneration, significantly accelerated axon d...

Rho GTPases and signaling networks.

The Rho GTPases form a subgroup of the Ras superfamily of 20to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man. The mammalian Rho-like GTPases comprise at least 10 distinct proteins: RhoA, B, C, D, and E; Rac1 and 2; RacE; Cdc42Hs, and TC10. A comparison of the amin...

Rho GTPases: Integrating Integrin Signaling

I-28: Role of Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Ki nase-Mediated Signaling Pathway in The Pathogenesis of Endometriosis-Associated Fibrosis

Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...

Smad3 regulates Rho signaling via NET1

Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Sciences, Korean Eye Tissue and Gene Bank Related to Blindness, College of Medicine, The Catholic University of Korea, Seoul, Korea. Running title: Smad3 regulates RhoA via NET1 in TGF-1-induced cells Address correspondence to: Choun-Ki Joo, Laboratory of Ophthalmology and Visual Science, Catholic Research ...